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UID:
CATEGORIES:ÖGMBT-Seminar OST
SUMMARY:A versatile protein (Albumin) and peptide (AlaGlu) with clinical significance
LOCATION:Krems at UWK (Universität für Weiterbildung Krems) in the seminar room SE 3
 .6. (Location updated!)
DESCRIPTION;ENCODING=QUOTED-PRINTABLE:	Prof. Dr. Ing. Jörg Vienken 	 \n\n\n	Abstract:\n\n\n	Current opi
 nion associates the success of extracorporeal blood purification therapies 
 to the quality of applied hardware, such as filters, tubing and monitors. H
 owever, properties of blood proteins and adminstered infusion solutions can
  also be considered determinants of therapeutic success.\n\n\n	Blood protei
 ns, and among them the most frequent protein albumin, are known for their b
 indung capacity for both endogenous and exogenous toxins, as well as for ph
 armaceutical drugs. The binding capacity of albumin determines albumin&acut
 e;s efficiency as a “molecular vacuum cleaner”. Under pathologi
 cal clinical conditions however, such as kidney or liver failure, a massive
  reduction in albumin binding is observed. This phenomenon can be attribute
 d to a modification in the 3D-conformation of this protein. Consequently, t
 he dogma of nephrologists that the dialysis membrane should be impermeable 
 for albumin has to be revised. It should be considered that under such path
 ological conditions a 3D-modifed albumin must be removed. Clincial trials h
 ave shown the superiority of protein peremable membranes in this respect.\n
 \n\n	 \n\n\n	Peritoneal dialysis (PD) technique patient survival remai
 ns challenging due to peritonitis and longterm alterations to peritoneal me
 mbrane function and integrity. Hence administering modified infusion soluti
 ons for PD may help to overcome this problem. A novel approach, supplementi
 ng such dialysis solutions with the dipeptide Alanyl-glutamine (AlaGlu), ha
 s proven to be a promising tool for improvement. Clinical trials with suppl
 emented infusion solutions with AlaGlu have shown benefits to surrogate mar
 kers of cell function in randomized controlled studies when peritoneal cell
 ular stress responses and leukocate function have been restored. \n\n\
 n	NOTICE: Location has changed to seminar room SE 3.6!\n\n\n	 \n\n\n	H
 osted by: Vladislav Semak\n\n\n	ÖGMBT SEMINAR EAST\n\n\n	 \n\n\n	
  \n
CONTACT:ÖGMBT SEMINAR EAST
DTSTAMP:20260509T214310Z
DTSTART;TZID=Europe/Vienna:20230503T130000
DTEND;TZID=Europe/Vienna:20230503T140000
SEQUENCE:1
TRANSP:OPAQUE
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