We are Austria’s largest research and technology organisation and an international player in applied research for innovative infrastructure solutions. This makes us a powerful development partner for industry and a top employer in the scientific community. Our Center for Health & Bioresources in Vienna invites applications for a:
PhD Thesis “The blood-brain barrier in rare neurodevelopmental diseases”
- Center for Health & Bioresources -
-
You work on the role of the blood-brain barrier in rare neurodevelopmental diseases such as rasopathies
-
You elucidate alterations in blood-brain barrier functionality based on mutations underlying the diseases.
-
You investigate the role of the communication between brain endothelial cells and CNS cells such as astrocytes, pericytes and neurons for disease progression and therapeutic approaches.
-
You combine high-throughput screening methods and cell culture models based on patient-derived human induced pluripotent stem cells (hiPSC) to evaluate the influence of mutations on the functionality of the blood-brain barrier.
-
You implement novel methods to study the relevance of the cellular microenvironment on treatment strategies.
-
You study drug transport (small molecules, nanoparticle carriers) under disease conditions.
-
You support and supervise master’s students in the lab, write conference contributions and publish results in leading scientific journals
-
You unravel changes at the blood-brain barrier in rare neurodevelopmental diseases and develop novel therapies using e.g., cutting edge hiPSC-based cell models and microscopic techniques.
-
You are integrated in an interdisciplinary team evaluating in vitro/in vivo correlations.
Your qualifications as an
Ingenious Partner:
-
MSc. in life sciences, e.g., molecular biology, molecular biosciences, molecular medicine, biotechnology, neurosciences, pharmaceutical sciences, or a related field
-
Experimental skills in cell culture (preferentially endothelial, epithelial, hiPS cells, fibroblasts), protein chemistry and molecular biology
-
Strong sense for responsibility and team spirit
-
Excellent communication skills in English
What to expect:
EUR 2,464.80 gross per month for 30 hours/week based on the collective agreement. There will be additional company benefits. You will be part of our international AIT PhD community and participate in our AIT PhD framework programme. As a research institution, we are familiar with the supervision and execution of PhD theses, and we are looking forward to supporting you accordingly!
At AIT, the promotion of women is important to us - that's why we are especially looking forward to applications from female students!
TOMORROW TODAY - WITH YOU?
Please submit your application documents including CV, cover letter and certificates online: https://jobs.ait.ac.at/Job/204558
For further information please contact:
Prof. Dr. Winfried Neuhaus, winfried.neuhaus@ait.ac.at
